Churg Strauss Syndrome Causes, Symptoms, Diagnosis And Treatment

Churg Strauss Syndrome

What Is Churg Strauss Syndrome?

Churg Strauss Syndrome is an autoimmune condition that causes inflammation of small and medium-sized blood vessels in persons with a history of airway allergic hypersensitivity.

It usually manifests in three stages

  • The early stage is marked by airway inflammation; almost all patients experienceasthma and/or allergic rhinitis.
  • The second stage is characterized by abnormally high numbers of eosinophils, which causes tissue damage, most commonly to thelungs and the digestive tract.
  • The third stage consists of vasculitis, which can eventually lead tocell death and can be life-threatening.

Causes Of Churg Strauss Syndrome:

The underlying cause of Churg-Strauss syndrome is yet unknown.

However, genetics and environmental factors are thought to play a role.

Possible risk factors include:

  • Age

On average, people with Churg-Strauss syndrome are diagnosed in their mid- to late 40s.

  • History of asthma or nasal problems

Most people diagnosed with Churg-Strauss syndrome have a history of nasal allergies, chronic sinusitis or asthma, which is often severe or hard to control.

Symptoms Of Churg Strauss Syndrome:

Symptoms vary according to the stages of Churg-Strauss syndrome,

  • Allergic stage
  • Asthma
  • Hay fever (allergic rhinitis).

This affects the mucous membranes of the nose, causing runny nose, sneezing and itching.

  • Sinus pain and inflammation (sinusitis).
  • Eosinophilic stage
  • Fever
  • Loss of appetite
  • Weight loss
  • Asthma
  • Fatigue
  • Cough
  • Abdominal pain
  • Gastrointestinal bleeding
  • Vasculitic stage
  • Rash or skin sores
  • Joint aches and swelling
  • Severe pain, numbness and tingling in your hands and feet (peripheral neuropathy)
  • Severe abdominal pain
  • Diarrhea, nausea and vomiting
  • shortness of breath (dyspnea) from asthma or congestive heart failure
  • Coughing up blood (hemoptysis)
  • Chest pain
  • Irregular heartbeat
  • Blood in your urine (hematuria)

Diagnosis Of Churg Strauss Syndrome:

Churg-Strauss syndrome is diagnosed if one falls under the following criteria:

  • Asthma
  • Eosinophils greater than 10% of a differential white blood cell count
  • Presence of mononeuropathy or polyneuropathy
  • Unfixed pulmonary infiltrates
  • Presence of paranasal sinus abnormalities
  • Histological evidence of extravascular eosinophils

Treatment Of Churg Strauss Syndrome:

Churg-Strauss syndrome cannot be cured.

However, it can be managed via intake of the following medications:

  • Other immunosuppressive drugs.
  • cyclophosphamide (Cytoxan),
  • azathioprine (Azasan, Imuran)
  • methotrexate (Rheumatrex, Trexall)
  • Immune globulin.
  • Biologic medications.
  • rituximab (Rituxan)

By : Natural Health News

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